IL-4 and IL-13 signaling in allergic airway disease
نویسندگان
چکیده
منابع مشابه
The role of IL-13 in established allergic airway disease.
The effectiveness of targeting IL-13 in models where airway hyperresponsiveness (AHR) and airway inflammation have already been established is not well-described. We investigated the effects of blocking IL-13 on the early and late phase airway responses and the development of AHR in previously sensitized and challenged mice. BALB/cByJ mice were sensitized (days 1 and 14) and challenged (days 28...
متن کاملassociation of the expression of il-4 and il-13 genes, il-4 and ige serum levels with allergic asthma
immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...
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Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glu...
متن کاملComplete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13-/- mice.
BACKGROUND T-helper type 2 (Th2)-derived cytokines such as IL-4, IL-5, IL-9 and IL-13 play an important role in the synthesis of IgE and in the promotion of allergic eosinophilic inflammation and airway wall remodelling. OBJECTIVE We determined the importance of IL-13 alone, and of the four Th2 cytokines together, by studying mice in which either IL-13 alone or the Th2 cytokine cluster was ge...
متن کاملSoluble St2 Blocks Il-33 Signaling in Allergic Airway Inflammation
SOLUBLE ST2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION Hiroko Hayakawa1, Morisada Hayakawa1, Akihiro Kume2, and Shin-ichi Tominaga1 From the 1Department of Biochemistry and 2Division of Genetic Therapeutics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan Running Title: Suppression of IL-33 signaling by soluble ST2 Address correspondence to: Moris...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2015
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2015.05.014